Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

1999年中国航空工业第一、第二集团公司(之后两者合并为中国航空工业集团公司)的成立标志着中国开始进军商业航天领域,显示了中国迈向这一行业的绝心与意志。但实现这一雄心的脚步并不那么平坦。20年之后毫无疑问中国已经成为了大型商用航天领域的成熟玩家,将其他几国远远甩在身后,并有望打破空客和波音的长期垄断。
In 2011, at age 15, D'Aloisio closed a seed round of funding from Li Ka-shing. A year later, Summly launched, and within a month it had attracted 500,000 users and became the number-one news app in 28 countries. The Yahoo! sale capped off a remarkable run for someone not yet out of high school. But it's not mere technological savvy that sets D'Aloisio apart. Since long before he could shave, he has been driven by an intense curiosity and a desire to make some sort of mark on the tech world. Not just to create but to build and, yes, to monetize.
addition
来源:前十网
单词avoid 联想记忆:
根据QS的这一排名,使得中国成为入选全球400强学校第二多的国家,仅次于有164所大学的学科入选全球400强的美国。英国排名第3,有78所大学进入榜单。
纳米比亚的货币几年来一直对许多其他货币贬值,为其他国家的旅客前来旅游提供了便利条件。最便宜的航班一般会避开南非和欧洲学校的放假时间,尤其是十二月末和一月份。
While Jodie Foster used to opt for the bathroom – “they looked good with the faucets” – she has since moved the two she won for The Accused and Silence of the Lambs to a much more orthodox spot: a trophy case.
Let’s now travel to Greece. There, Andreas Georgiou, the head of its statistical agency between 2010 and 2015, faces prosecutions for his part in uncovering fake Greek public finance data for 2009 and setting the record straight. This week 40 groups, led by the American Statistical Association, and 651 individuals signed a statement in support of Mr Georgiou.
4. China will continueefforts to build out C-9 (the top nine universities in China) in the form ofmore than $1 billion new investments in major campuses. Funds will becommitted to attract top faculty, build state-of-the-art facilities, andrecruit the very best students. China will lock into a global war forintelligence, education, and skill.
It was also the "most liked" tweet of the year, with 4.59 million likes.
5.匈牙利德布勒森
一些银行仍然给予股东高额回报。中国招商银行十分“大方”,其分红占净利润的30.16%。
de下,put放-下放权力-代理
我倒是并不担心费城、凤凰城和明尼苏达的球队。他们队伍都很年轻,都在重建的路上。如果他们能够取得进步,那很好,就算没有,他们也能获得高顺位的选秀权。而篮网队则是另一个故事了,我们稍后会讨论到他们。
8. 赤脚能够提高记忆力
《钢铁侠3》(Iron Man 3)凭借12亿美元的票房总收入成为目前2013年最卖座影片。不过这还不足以令其主演小罗伯特·唐尼(Robert Downey Jr.)摘下我们票房收入最高演员的桂冠。今年,绰号“巨石强森”的德韦恩·约翰逊(Dwayne Johnson)凭借更加努力的工作,击败了唐尼。
而在进口一侧,不论以人民币还是美元计,情况都愈发糟糕。
今年初,执政的共产党设定了今年贸易增长6%的目标,但2015年头十个月的贸易总额同比下降逾8%。
“We sincerely apologize to Moonlight, La La Land, Warren Beatty, Faye Dunaway, and Oscar viewers for the error that was made during the award announcement for Best Picture. The presenters had mistakenly been given the wrong category envelope and when discovered, was immediately corrected.”
日本三巨头:在本田的美国化管理团队将新品投放市场之前,该公司还会原地踏步,尤其是它的讴歌NSX超跑,这款车型已经在各大车展上亮相好几年了,但至今仍未上市。本田CEO卡洛斯o高森一边督促高管团队努力实现他的“三年计划”目标,一边培养继承人。《汽车新闻》报道称,丰田公司在携新产品搬离南加州工厂之前,正处于“马力全开”的状态。
他表示,目前腾讯旗下的游戏和直播应用不需要实名注册,不过腾讯公司正在考虑建立一个平台,以方便家长监护孩子的行为。
vi. 打结
“像这样的问题是极为紧要的,尽管不一定通过言语表达了出来。”
担忧、紧张、抑郁和愤怒等负面情绪更常在D型人格的人身上体现。一件常常被他人忽视的小事就可能让D型人格的人烦恼,甚至会破坏他的心情。


Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.
贝拉是该榜单上最年轻的模特,她上个月刚满21岁。
6.Gal Gadot


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

在此次颁奖典礼上,麦肯锡全球董事总经理鲍达民(Dominic Barton)在典礼上还颁发了“布拉肯贠尔”青年商业作家奖(Bracken Bower Prize for young business writers),获奖者为克里斯托弗克利尔菲尔德(Christopher Clearfield)和安德拉什舠尔奇克(András Tilcsik)。他们计划出版的图书将会探索企业如何能够管控发生灾难性失败的风险。该奖项面向35岁以下作者,专门颁发给那些探讨增长所构成的挑战和机遇的商业图书计划,奖金为1.5万英镑。
camp(n 田野,营地),aign名词后缀-营地-备战的地方
5.射击类比赛项目
但是,是什么推动了乐观或悲观情绪呢?库迪斯与巴塞罗那庞培法布拉大学(Universitat Pompeu Fabra)的汉斯-乔亚吉姆o沃斯发现了一些令人意外的答案。

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

TextPride was a fine business, but a tiny one. Meanwhile, the market for messaging apps was exploding. Facebook FB 0.61% bought WhatsApp for $19 billion; that service now has 700 million monthly active users. Tango, an app with 250 million registered users, is worth $1.5 billion. Kik has 200 million registered users. Snapchat, worth $10 billion, has 100 million users. A new study, commissioned by Kik, shows that U.S. users now spend more time on average in messaging apps than they do on social networking apps. The only problem? These messaging apps need ways to make money, and there’s no reasonable way for advertisers to wedge themselves into conversations between friends.

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

怎么做煎饼?
我们当中很多人都有八卦抱怨的习惯。但是如果做的太频繁的话,工作恐怕就不保了。所有的这些会带来一个同样的结果:变成了老板的眼中的麻烦。一般来讲,老板要确保自己的团队有正面的能量,团队中如果有人是消极的,会有损他的形象。消极的员工在高级管理层中被认为是“癌细胞”,这是因为“他们早晚会被割除”。如果你有怨念的话,一个好的办法就是私底下直接和老板对话。 千万不要一开始就拉拢人心寻求支持。

只要看到球馆没有别的赞助商的大名——除了Smoothie King,一家当地的饮品店——就知道鹈鹕面临着什么样的严重问题(相比之下,圣徒队的主场就是他们隔壁的梅赛德斯-奔驰超圆屋顶体育场)。
complain
愿你一切称心如意,快乐无比。
According to Brandi Bennett at HostGator.com,maintaining a blog on a well-hosted website, or volunteering your time and skills, shows instead of tells the community, and thereby builds expertise and trust.
Winners: Thunder
哈佛大学连续16年位居榜首,斯坦福大学和剑桥大学仍分别位列第二、第三名。

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


昆明:万盏太阳能LED路灯点亮偏远村寨


References

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2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


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But as Western manufacturing and industry have declined, taking many working-class towns with them, parents and grandparents have found that the opportunities they once had are unavailable to the next generation.
中国的创新表现有所改善,在"创新质量"方面排名第17,这是个考量高校水平、科学出版物数量和国际专利申请量的指标。
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201109/155435.shtmlIn August, Jose Javier - from the city of Torrevieja - created an account with AdWords, a Google pay-per-click service.
投资者也关注到了本田的这一困境。尽管在席卷全球的金融危机中,本田是全球少数几家能独善其身、避免严重亏损的汽车厂商之一,但在过去几年中,其普通股股价下跌了17.2%,而同期日经225指数却上涨了7.4%,丰田汽车的股价也上涨了19.5%。
一、2016年工作回顾
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Argentina, the host nation's big rivals, are in with a great chance too. Any team featuring Lionel Messi is going to be in with a shout, but when you add to that the likes of Sergio Aguero, Gonzalo Higuain and Ezequiel Lavezzi, then it's a team with one of the best sets of attacking options in the tournament. Likewise, Uruguay's attacking trio of Luis Suarez, Edinson Cavani and Diegoi Forlan is about as potent as it can get, and is capable of scoring goals against any team in the world, although whethere the rest of their team is strong enough is open to debate.
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Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



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Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

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随着美国电子商务交易接近零售总额的10%,越来越多的商家开始寻找既好用又能帮他们快速卖出商品的电商平台。
台风艾玛
本周二在竞选的最后阶段,罗姆尼还前往俄亥俄州和宾夕法尼亚州,希望能在这些摇摆州取得选票支持。奥巴马竞选阵营这边,副总统拜登也前往了俄亥俄州,奥巴马本人留守芝加哥。
在证监会分类的18个行业中,金融业高管以2736万元的年薪排名第一,地产业高管以1118万元的年薪位居次席。

欧洲工商管理学院(Insead)领衔2017年英国《金融时报》全球MBA百强榜。这是这所拥有多个校区的国际商学院连续第二年高居榜首,去年该学院首次摘得桂冠。

  • Only the first three authors are listed, followed by "et al."
  • 黄金周一线楼市成交趋缓 三四线楼市仍惨淡
  • 北京市住建部门专项检查通州中介


中国拥有世界上最大的外汇储备,它一直被视为金融稳定的最终保障,因为外储可以被用来对冲资本外流,或纾困艰难应对坏账增加的国内金融机构。
President Obama leads the pack. On top of the $400,000 a year, he gets a tax-free expense account worth $50,000. The salary was last raised by Congress in 2001.

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